The role of basal forebrain neurons in tonic and phasic activation of the cerebral cortex
Identifieur interne : 003639 ( Main/Exploration ); précédent : 003638; suivant : 003640The role of basal forebrain neurons in tonic and phasic activation of the cerebral cortex
Auteurs : Lászl Détári [Hongrie] ; Douglas D. Rasmusson [Canada] ; Kazue Semba [Canada]Source :
- Progress in Neurobiology [ 0301-0082 ] ; 1999.
Abstract
The basal forebrain and in particular its cholinergic projections to the cerebral cortex have long been implicated in the maintenance of cortical activation. This review summarizes evidence supporting a close link between basal forebrain neuronal activity and the cortical electroencephalogram (EEG). The anatomy of basal forebrain projections and effects of acetylcholine on cortical and thalamic neurons are discussed along with the modulatory inputs to basal forebrain neurons. As both cholinergic and GABAergic basal forebrain neurons project to the cortex, identification of the transmitter specificity of basal forebrain neurons is critical for correlating their activity with the activity of cortical neurons and the EEG. Characteristics of the different basal forebrain neurons from in vitro and in vivo studies are summarized which might make it possible to identify different neuronal types. Recent evidence suggests that basal forebrain neurons activate the cortex not only tonically, as previously shown, but also phasically. Data on basal forebrain neuronal activity are presented, clearly showing that there are strong tonic and phasic correlations between the firing of individual basal forebrain cells and the cortical activity. Close analysis of temporal correlation indicates that changes in basal forebrain neuronal activity precede those in the cortex. While correlational, these data, together with the anatomical and pharmacological findings, suggest that the basal forebrain has an important role in regulating both the tonic and the phasic functioning of the cortex.
Url:
DOI: 10.1016/S0301-0082(98)00084-7
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002205
- to stream Istex, to step Curation: 002205
- to stream Istex, to step Checkpoint: 001278
- to stream Main, to step Merge: 003C18
- to stream Main, to step Curation: 003639
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>The role of basal forebrain neurons in tonic and phasic activation of the cerebral cortex</title><author><name sortKey="Detari, Laszl" sort="Detari, Laszl" uniqKey="Detari L" first="Lászl" last="Détári">Lászl Détári</name></author><author><name sortKey="Rasmusson, Douglas D" sort="Rasmusson, Douglas D" uniqKey="Rasmusson D" first="Douglas D" last="Rasmusson">Douglas D. Rasmusson</name></author><author><name sortKey="Semba, Kazue" sort="Semba, Kazue" uniqKey="Semba K" first="Kazue" last="Semba">Kazue Semba</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:69402442C94221AF8134811CA16516CD6D8930C9</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0301-0082(98)00084-7</idno><idno type="url">https://api-v5.istex.fr/document/69402442C94221AF8134811CA16516CD6D8930C9/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002205</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002205</idno><idno type="wicri:Area/Istex/Curation">002205</idno><idno type="wicri:Area/Istex/Checkpoint">001278</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001278</idno><idno type="wicri:doubleKey">0301-0082:1999:Detari L:the:role:of</idno><idno type="wicri:Area/Main/Merge">003C18</idno><idno type="wicri:Area/Main/Curation">003639</idno><idno type="wicri:Area/Main/Exploration">003639</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">The role of basal forebrain neurons in tonic and phasic activation of the cerebral cortex</title><author><name sortKey="Detari, Laszl" sort="Detari, Laszl" uniqKey="Detari L" first="Lászl" last="Détári">Lászl Détári</name><affiliation wicri:level="3"><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Comparative Physiology, Eötvös Loránd University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Rasmusson, Douglas D" sort="Rasmusson, Douglas D" uniqKey="Rasmusson D" first="Douglas D" last="Rasmusson">Douglas D. Rasmusson</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology and Biophysics, Dalhousie University, Halifax, N.S.</wicri:regionArea><wicri:noRegion>N.S.</wicri:noRegion></affiliation></author><author><name sortKey="Semba, Kazue" sort="Semba, Kazue" uniqKey="Semba K" first="Kazue" last="Semba">Kazue Semba</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy and Neurobiology, Dalhousie University, Halifax, N.S.</wicri:regionArea><wicri:noRegion>N.S.</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Progress in Neurobiology</title><title level="j" type="abbrev">PRONEU</title><idno type="ISSN">0301-0082</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">58</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="249">249</biblScope><biblScope unit="page" to="277">277</biblScope></imprint><idno type="ISSN">0301-0082</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0301-0082</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The basal forebrain and in particular its cholinergic projections to the cerebral cortex have long been implicated in the maintenance of cortical activation. This review summarizes evidence supporting a close link between basal forebrain neuronal activity and the cortical electroencephalogram (EEG). The anatomy of basal forebrain projections and effects of acetylcholine on cortical and thalamic neurons are discussed along with the modulatory inputs to basal forebrain neurons. As both cholinergic and GABAergic basal forebrain neurons project to the cortex, identification of the transmitter specificity of basal forebrain neurons is critical for correlating their activity with the activity of cortical neurons and the EEG. Characteristics of the different basal forebrain neurons from in vitro and in vivo studies are summarized which might make it possible to identify different neuronal types. Recent evidence suggests that basal forebrain neurons activate the cortex not only tonically, as previously shown, but also phasically. Data on basal forebrain neuronal activity are presented, clearly showing that there are strong tonic and phasic correlations between the firing of individual basal forebrain cells and the cortical activity. Close analysis of temporal correlation indicates that changes in basal forebrain neuronal activity precede those in the cortex. While correlational, these data, together with the anatomical and pharmacological findings, suggest that the basal forebrain has an important role in regulating both the tonic and the phasic functioning of the cortex.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Hongrie</li></country><region><li>Hongrie centrale</li></region><settlement><li>Budapest</li></settlement></list><tree><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Detari, Laszl" sort="Detari, Laszl" uniqKey="Detari L" first="Lászl" last="Détári">Lászl Détári</name></region></country><country name="Canada"><noRegion><name sortKey="Rasmusson, Douglas D" sort="Rasmusson, Douglas D" uniqKey="Rasmusson D" first="Douglas D" last="Rasmusson">Douglas D. Rasmusson</name></noRegion><name sortKey="Semba, Kazue" sort="Semba, Kazue" uniqKey="Semba K" first="Kazue" last="Semba">Kazue Semba</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003639 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003639 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:69402442C94221AF8134811CA16516CD6D8930C9
|texte= The role of basal forebrain neurons in tonic and phasic activation of the cerebral cortex
}}
| This area was generated with Dilib version V0.6.29. |  |